Patent · US Expired

Compositions with controlled zero-order delivery rate and method of preparing these compositions

US5219575A · kind A · utility

58Cited by

5References

5Claims

0Family size

Assignee

Duphar International Research B.V. · NL

Inventors

Elvira M. G. Van Bommel · Weesp, NL
Jasper G. Fokkens · Weesp, NL

Key dates

Filing date	Aug 20, 1990
Grant date	Jun 15, 1993
Priority date	—
Expiry date	Aug 20, 2010

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K9/1676
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compositions having a controlled zero-order delivery rate of the active component. The composition comprises a core or a protective layer coated with a continuous matrix of constant composition containing such a mixture of active substance(s) and excipient(s) that the concentration of the active substance(s) decreases from the core or the protective layer towards the outside, and the concentration of the excipient(s) increases in the same direction, whereas the sum of two substantially remains constant over the whole distance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.