8 beta-substituted ergolines, process for their production and their use

US5219862A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerhard Sauer · Berlin, DE
• Thomas Brumby · Berlin, DE
• Helmut Wachtel · Berlin, DE
• Jonathan Turner · Berlin, DE
• Peter-Andreas Loschmann · Berlin, DE

Key dates

• Filing date: Dec 21, 1990
• Grant date: Jun 15, 1993
• Expiry date: Dec 21, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which R.sup.2 means optionally substituted C.sub.1-7 alkyl, C.sub.2-7 alkenyl, CH.sub.2 --O--C.sub.1-4 alkyl or CH.sub.2 --S--C.sub.1-4 alkyl PA0 R.sup.6 means C.sub.2-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-5 -cycloalkyl-C.sub.1-2 alkyl and PA0 R.sup.8 means CH.sub.2 --X, ##STR2## in which X stands for CN, OCH.sub.3, SCH.sub.3 or CONH.sub.2 and R.sup.1 stands for hydrogen, halogen, methyl or methoxy, and R.sup.3 and R.sup.4 each mean C.sub.1-4 alkyl or (CH.sub.2).sub.n --N(CH.sub.3).sub.2, in which n=1-4, and their acid addition salts, the process for their production, their use as pharmaceutical agents as well as intermediate compounds are described.