Heterocyclic acids
US5219874A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 20, 1991 |
| Grant date | Jun 15, 1993 |
| Priority date | — |
| Expiry date | Sep 20, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns novel 1,3-dioxane alkenoic acid derivatives of the formula I ##STR1## wherein: n is the integer 1 or 2; PA1 Y is methyleneoxy, vinylene or ethylene; PA1 A.sup.1 is (1-6C)alkylene; PA1 R.sup.1 is a group of the formula R.sup.2.A.sup.2 --, in which: PA2 R.sup.2 is phenyl unsubstituted or bearing up to three substituents which are independently selected from (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkanoyl, (1-6C)alkylthio, (1-6C)alkylsulphonyl, halogeno, trifluoromethyl, nitro and cyano; PA2 A.sup.2 is a direct bond to R.sup.2 or a group of the formula --W--C(R.sup.4)(R.sup.5)-- wherein W is oxygen, methylene or a direct bond to R.sup.2, and R.sup.4 and R.sup.5 are independently (1-4C)alkyl; PA1 Q is a heterocyclyl group selected from thiazol-5-yl and imidazol-5-yl, the latter being unsubstituted or bearing a (1-12C)alkyl group at the 1-position of the imidazole ring; and PA1 R.sup.3 is hydroxy, a physiologically acceptable alcohol residue, or (1-4C)alkanesulphonamido; or a pharmaceutically acceptable salt thereof. The compounds are thromboxane A.sub.2 antagonists and inhibitors of thromboxane A.sub.2 synthase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.