Gem-diamino derivatives and their use in the synthesis of retro-inverso peptides
US5219988A · kind A · utility
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5References
11Claims
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Key dates
| Filing date | Feb 21, 1990 |
| Grant date | Jun 15, 1993 |
| Priority date | — |
| Expiry date | Feb 21, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0212
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to new gem-diamino derivatives of general formula (I) ##STR1## where R is the side chain of an amino acid, of which any functional groups are suitably protected, and PA0 X is an acyl group chosen from the group consisting of 2-nitrobenzoyl, 4-chloro-butyryl, acetoacetyl, 4-bromo-butyryl, (2-nitrophenoxy)-acetyl and 2-methyl-2-(2'-nitro-phenoxy)propionyl, of use in introducing gem-diamino residues into retro-inverso peptides. The invention further relates to a method for the synthesis of retro-inverso peptides in which the gem-diamino residue or residues are introduced using the new compound (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.