DNA sequence useful for the detection of Alzheimer's disease
US5220013A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 30, 1989 |
| Grant date | Jun 15, 1993 |
| Priority date | — |
| Expiry date | Nov 30, 2009 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related proteins and recombinant or synthetic immunogenic peptides. These sequences are also used to identify genomic mutations and/or restriction site alterations which are associated with a predisposition to Alzheimer's disease, for purposes of genetic screening. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.