Cyclcic FR-900520 microbial biotransformation agent
US5221625A · kind A · utility
6Cited by
5References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 10, 1992 |
| Grant date | Jun 22, 1993 |
| Priority date | — |
| Expiry date | Jan 10, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/899
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6963) ATCC No. 55230. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.