Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them
US5221689A · kind A · utility
0Cited by
7References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1992 |
| Grant date | Jun 22, 1993 |
| Priority date | — |
| Expiry date | Jan 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0015
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel isomers of 6,9.alpha.-nitrilo-PGI.sub.1 s having a specific steric configuration, which are replaced by an alkyl (C.sub.1 to C.sub.8)-substituted cycloalkyl (C.sub.4 to C.sub.7) group in (1S,S) form, in (1S,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.