Reagents for rapid peptide synthesis
US5221754A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1992 |
| Grant date | Jun 22, 1993 |
| Priority date | — |
| Expiry date | Sep 14, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to compounds of the formula: ##STR1## wherein R is an electron withdrawing group; PA1 R.sub.1 is H or COZ; PA1 X.sub.1 and X.sub.2 are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or R and X.sub.1 taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and PA1 Z is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.