Production chromatography process using a critical angle refractive index detector
US5223142A · kind A · utility
7Cited by
5References
1Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 18, 1992 |
| Grant date | Jun 29, 1993 |
| Priority date | — |
| Expiry date | Aug 18, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/43
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A critical angle refractive index detector for production liquid chromatography systems with flow rates as low as 100 ml/min to 25 l/min or higher as the system requires and pressures up to 4000 psi. The detector includes a flow cell with a sensing chamber volume selected to provide maximum detector sensitivity and minimum pressure drop at the maximum flow rate of the system for accurate discernment of critical refractive index peaks of each constituent in the sample. Explosion protected controls for zero and span settings are located to the exterior of a purged safe enclosure containing the system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.