Thrombolytically active non-glycosylated protein

US5223256A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Anne Stern · Penzberg, DE
• Ulrich Kohnert · Habach, DE
• Rainer Rudolph · Waldshut-Tiengen, DE
• Stephan Fischer · Weilheim, DE
• Ulrich Martin · Mannheim, DE

Key dates

• Filing date: Sep 28, 1990
• Grant date: Jun 29, 1993
• Expiry date: Sep 28, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A new thrombolytically active protein is not glycosylated and consists of the following amino acid sequence: ##STR1## or said amino acid sequence with an additional N-terminal methionine. DNA sequences encoding the thrombolytically active, non-glycosylated protein and pharmaceutical compositions containing said protein are also disclosed. The protein possesses particularly favorable properties when used to dissolve blood clots.