Recombinant DNA molecule comprising lymphocyte function-associated antigen 3 phosphatidylinositol linkage signal sequence
US5223394A · kind A · utility
33Cited by
1References
15Claims
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Key dates
| Filing date | Apr 10, 1989 |
| Grant date | Jun 29, 1993 |
| Priority date | — |
| Expiry date | Apr 10, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/912
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
DNA sequences derived from a phosphatidylinositol-linked form of lymphocyte function-associated antigen 3 ("LFA-3") are provided which code for a phosphatidylinositol linkage signalling sequence. The linkage signalling sequence may be linked to DNA coding for secretory proteins or polypeptides to obtain phosphatidylinositol-linked chimeric proteins or polypeptides. The chimeric proteins can be used to produce targeted drugs, to form micellular or liposomal drug delivery systems, or to improve the purification or screening of particular cells, proteins or DNA libraries.
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