Cyclic antitumor compounds
US5223506A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 4, 1991 |
| Grant date | Jun 29, 1993 |
| Priority date | — |
| Expiry date | Jun 4, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to certain substituted tetracyclic fused quinoline derivatives of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo, methoxy or amino; PA0 R.sup.2 is hydrogen, hydroxy, methoxy or amino; PA0 R.sup.3 is hydrogen, hydroxy, methoxy, methoxymethoxy, amino, --OCONH.sub.2, [2(5H)-3,4-dihydro-3-oxyfuranone], 2-hydroxyethoxy, 2-aminoethoxy, 3-hydroxypropoxy or 3-aminopropoxy; or taken together with R.sup.2 or R.sup.4, methylenedioxy or ethylenedioxy; PA0 R.sup.4 is hydrogen, hydroxy or amino; PA0 Z is --CH.sub.2 --, --O-- or --NH--; and PA1 a) X.sup.1 is hydrogen; X.sup.2 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo or methoxy; and X.sup.3 is hydrogen or hydroxy; or PA1 b) X.sup.2 taken together with X.sup.3 is methylenedioxy or ethylenedioxy, and X.sup.1 is hydrogen or a pharmaceutically acceptable salt thereof provided that: PA0 i) at least one of R.sup.1 through R.sup.4 is other than hydrogen; PA0 ii) when R.sup.1 is methoxy, R.sup.2 is hydroxy or methoxy, R.sup.3 is hydrogen or methoxy and R.sup.4 is hydrogen; PA0 iii) when R.sup.2 is hydroxy, methoxy or amino, R.sup.3 is hydrogen, hydroxy or methoxy, and R.sup.4…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.