Heterocyclically substituted cycloalkano[b]-indolesulphonamides

US5223517A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Muller · Wuppertal, DE
• Ulrich Niewohner · Wermelskirchen, DE
• Elisabeth Perzborn · Wuppertal, DE
• Erwin Bischoff · Wuppertal, DE
• Hans-Georg Dellweg · Wuppertal, DE

Key dates

• Filing date: Aug 23, 1991
• Grant date: Jun 29, 1993
• Expiry date: Aug 23, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydrazines with cycloalkanones or by subsequent introduction of the heterocyclic group into appropriate indole derivatives. The heterocyclically substituted cycloalkano[b]-indolesulphonamides can be employed for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, asthma, allergies and for the prophylaxis of myocardial infarcts.