Tramadol N-oxide material, enantiomers and compositions thereof, and their use
US5223541A · kind A · utility
10Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 13, 1991 |
| Grant date | Jun 29, 1993 |
| Priority date | — |
| Expiry date | Sep 13, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.