Chemical modification method of diastereomer and separation method thereof
US5223647A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 1992 |
| Grant date | Jun 29, 1993 |
| Priority date | — |
| Expiry date | Jun 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/85
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses a separating and purifying (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone comprising the steps of: PA0 reacting a diastereomer mixture of (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (I) ##STR1## and (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone represented by the formula (II) ##STR2## with a reagent which reacts with the hydroxyl groups at least equimolar to the compound represented by the formula (II) to thereby convert the compound represented by the formula (II) into (4S, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone derivative represented by the formula (III) ##STR3## (where R represents a group modifying the hydroxyl group) by modification with priority of the hydroxyl group in the formula (II), and PA0 separating the compound of the formula (I) from the compound of the formula (III) through the difference in solubility to water or an organic solvent. According to the invention, (4R, 6R)-4-hydroxy-2,2,6-trimethyl cyclohexanone is easily separated with a high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.