Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi

US5225181A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Suresh C. Srivastava · Port Jefferson, US
• Barry S. Coller · New York, US
• George E. Meinken · Middle Island, US

Key dates

• Filing date: Jan 21, 1992
• Grant date: Jul 6, 1993
• Expiry date: Jan 21, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a radiolabeled monoclonal antibody of the class IgG.sub.1 which reacts readily with both normal human and dog blood platelets while failing to react with thrombasthenic human platelets. This antibody has the property of completely blocking interaction of fibrinogen with platelets induced by ADP, and the ability to detect fresh thrombi in vivo.