Transdermal administration of short or intermediate half-life benzodiazepines
US5225198A · kind A · utility
17Cited by
3References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 27, 1991 |
| Grant date | Jul 6, 1993 |
| Priority date | — |
| Expiry date | Aug 27, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolamine or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The composite comprises an impermeable backing layer and a reservoir layer containing the benzodiazepine and a permeation enhancer combined with a solvent-based acrylic polymer adhesive with the amounts of benzodiazepine and enhancer being sufficient to cause the benzodiazepine to pass through the skin at a rate in excess of about one .mu.g/cm.sup.2 /hr.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.