Antimicrobial amphiphilic peptides

US5225399A · kind A · utility

Assignee

• THE CHILDREN'S HOSPITAL OF PHILADELPHIA · US

Inventors

• Michael Zasloff · Yeadon, US
• W. Lee Maloy · Lansdale, US
• U. Prasad Kari · Lansdale, US
• Michael Brasseur · Saginaw, US

Key dates

• Filing date: Apr 15, 1991
• Grant date: Jul 6, 1993
• Expiry date: Apr 15, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A biologically active peptide which includes the following structure: EQU R.sub.1 -R.sub.1 -R.sub.1 -R.sub.4 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1a -R.sub.1 -R.sub.1 -R.sub.3 -R.sub.2 R.sub.2 -R.sub.1a R.sub.1 and R.sub.1a are hydrophobic amino acids, R.sub.2 is a basic hydrophilic amino acid, R.sub.3 is a neutral hydrophilic amino acid, and R.sub.4 is hydrophobic or basic hydrophilic amino acid. Preferably, R.sub.1a is cysteine. Examples of peptides have the following structural formulae: PA1 (SEQ ID NO:1); PA1 (SEQ ID NO:2); PA1 (SEQ ID NO:3); PA1 (SEQ ID NO:4); PA1 (SEQ ID NO:5); and PA1 (SEQ ID NO:6). The peptide may be employed in a pharmaceutical composition.