Symmetrical bipeptides containing a polyalkylene glycol residue, method of preparation and use in the assay of proteases
US5225532A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 17, 1991 |
| Grant date | Jul 6, 1993 |
| Priority date | — |
| Expiry date | Oct 17, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/804
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The new invention relates, by way of novel industrial products, to compounds selected from PA0 (i) the symmetrical amino acids and peptides of the formula EQU R--A--B--CO--Q--CO--B--A--R (I) PA0 in which PA1 Q is a polyalkylene glycol residue selected from the polyethylene glycol and polypropylene glycol residues of the formula EQU --O[CH(X)CH.sub.2 O]-- PA1 in which X is H or Me and n is an integer greater than or equal to 1, PA1 B is a single bond, a monoamino acid residue or a peptide chain comprising from 2 to 9 monoamino acid residues, PA1 A is a basic monoamino acid residue selected from the group consisting of .alpha.-amino acid residues containing a basic group on a side-chain, and PA1 R is a labeling means making it possible to develop the enzyme substance to be identified or assayed; and PA0 (ii) their addition salts. These novel compounds are useful as substrates for the assay of enzymes, especially proteases and peptidases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.