Recombinant altered antibodies and methods of making altered antibodies
US5225539A · kind A · utility
1,834Cited by
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23Claims
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Key dates
| Filing date | Oct 25, 1991 |
| Grant date | Jul 6, 1993 |
| Priority date | — |
| Expiry date | Oct 25, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.