Processes for purification of 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine
US5225555A · kind A · utility
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3References
29Claims
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Key dates
| Filing date | Aug 19, 1992 |
| Grant date | Jul 6, 1993 |
| Priority date | — |
| Expiry date | Aug 19, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/50
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention involves two processes for the purification of a mixture of 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine (III) ##STR1## and 4,6-di(1-pyrrolidinyl)-2-chloropyrimidine (IV) ##STR2## to where <1.0% of 4,6-di(1-pyrrolidinyl)-2-chloropyrimidine (IV) is present. In addition also disclosed is a process which not only purifies 2,4-di(1-pyrrolidinyl)-6-chloropyrimidine (III) but produces the commercially important 2,4-di(1-pyrrolidinyl)-6-(1-piperazinyl)pyrimidine (IX) directly.
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