Preparation of 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one
US5225603A · kind A · utility
14Cited by
2References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 17, 1988 |
| Grant date | Jul 6, 1993 |
| Priority date | — |
| Expiry date | Jun 17, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An intermediate for the manufacture of nabumetone, 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one, is prepared by contacting 2-bromo-6-methoxynaphphalene with methyl vinyl ketone in the presence of a palladium catalyst at from about 50.degree. C. to about 200.degree. C. for a time sufficient to cause substantially complete reaction to occur.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.