Monoclonal antibody NUH2 capable of inactivating motility of human sperm, antigen defined by said monoclonal antibody and methods of using said monoclonal antibody and antigen

US5227160A · kind A · utility

Assignees

• The Biomembrane Institute · US
• Hyogo Medical College · JP

Inventors

• Edward Nudelman · Seattle, US
• Tokio Kaizu · Seattle, US
• Ulla Mandel-Clausen · Seattle, US
• Steven B. Levery · Seattle, US
• Sen-itiroh Hakomori · Seattle, US
• Yoshiyuki Tsuji · Kasai, JP
• Shinzo Isojima · Nishinomiya, JP

Key dates

• Filing date: Jul 15, 1988
• Grant date: Jul 13, 1993
• Expiry date: Jul 15, 2008

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/811
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Monoclonal antibody NUH2 produced by a hybridoma having ATCC deposit no. HB 9762. An isolated antigen capable of specifically binding to anti-human sperm antibodies including NUH2 and comprising at least an epitope having a sialyl I structure, and any analogues derived from said antigen. Methods of using the monoclonal antibody and antigen for contraception and treating infertility in human females.