Liposphere delivery systems for local anesthetics
US5227165A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1992 |
| Grant date | Jul 13, 1993 |
| Priority date | — |
| Expiry date | Jan 22, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2989
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A local anesthetic microsuspension system is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid anesthetic such as lidocaine or marcaine, or an anesthetic dispersed in an inert solid vehicle, such as a wax. Anesthetic lipospheres provide a controlled delivery of local anesthetics to achieve extended, effective relief from pain by slowly releasing the anesthetic from the solid hydrophobic core. This is highly preferred over the situation in which an aqueous solution of local anesthetic must be frequently administered because it is quickly systemically absorbed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.