Process for the preparation of 3'-aminopropyl 2-chloroethyl sulfone semisulfate

US5227527A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Angenendt · Frankfurt am Main, DE
• Michael Meier · Frankfurt am Main, DE

Key dates

• Filing date: Jun 10, 1992
• Grant date: Jul 13, 1993
• Expiry date: Jun 10, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of 3'-aminopropyl 2-chloro- ethyl sulfone semisulfate in very good yield and high purity, by reacting allylamine with mercaptoethanol in a one-pot process in about 0.5 to about 0.6 mol of dilute sulfuric acid, relative to allylamine, at temperatures of about 0.degree. C. up to the boiling point of the reaction mixture in the presence of a free-radical initiator, introducing 2.0 to about 2.5 mol of chlorine into the resultant reaction mixture at temperatures of about 0.degree. C. to about 100.degree. C. and then concentrating the mixture obtained to dryness.