Demonstration by in vivo measurement of reflection ultrasound analysis of improved bone quality following slow-release fluoride treatment in osteoporosis patients
US5228445A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 26, 1991 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Dec 26, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2291/269
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention involves a treatment process for improving the intrinsic quality of bone in osteoporotic patients. This can reduce the frequency of spinal fractures by inducing formation of bone which is mechanically stronger than that which it replaces. The process preferably comprises: administering an enteral form of sodium fluoride to maintain an individual's serum fluoride level from about 100 to about 200 ng/ml with a circadian fluctuation of less than about 75 ng/ml, and dietarily supplementing said individual with absorbable calcium (preferably calcium citrate). In one embodiment, sodium fluoride administration is interrupted temporarily (for about 30 to about 60 days in a 13 or 14 month cycle) to prevent loss of fluoride effectiveness and avert impaired mineralization of bone. Calcium is preferably maintained by an enteral dose of about 400 mg calcium twice daily. A vitamin D preparation may also be administered to the individual to further enhance bone strengthening. As a method for assessing response, periodic noninvasive in vivo measurements of intrinsic bone quality are made by reflection ultrasound, and the treatment regimen is maintained, altered or discontinued based …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.