Methods and pharmaceutical compositions for treating episodic heartburn
US5229137A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 6, 1992 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | May 6, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical medications and methods are disclosed for providing instant and sustained relief from pain or symptoms associated with episodic heartburn in humans. The medications consist essentially of antacids and histamine H.sub.2 -receptor antagonists, and may be administered on an as-needed basis in liquid or solid dosage forms. Typical antacids which may be used in combination with the histamine H.sub.2 -receptor antagonist are conventional antacids which are well known and widely used in the treatment of excess acid related gastrointestinal dysfunctions. Exemplary of typical antacids include, sodium bicarbonate, calcium carbonate, magnesium hydroxide and aluminum hydroxide, as well as commercially available high potency, flavored antacids. Histamine H.sub.2 -receptor antagonists which may be used in combination include those conventionally used in the treatment of peptic ulcers, such as, for example, cimetidine, ranitidine, famotidine and nizatidine. In carrying out the methods, an antacid and histamine H.sub.2 -receptor antagonist may be administered together as a single unitary dose in the form of a liquid or solid, or administered together, but separately as either liquid…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.