In-vitro method for producing antigen-specific human monoclonal antibodies
US5229275A · kind A · utility
366Cited by
1References
8Claims
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Key dates
| Filing date | Apr 26, 1990 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Apr 26, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/23
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of amplifying production of IgG, IgA and IgM antigen specific human monoclonal antibodies from transformed, T-cell depleted, human peripheral blood lymphocytes through the use of an adjuvant system consisting of 8-mercaptoguanosine and at least one of the cytokines interleukin-4 and interleukin-6. Also included in the invention is the adjuvant system and a kit comprising the system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.