Process for the continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid
US5229280A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 1989 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Feb 21, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/921
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid consisting in the reaction of a racemic (R,S) ester of 2-(6-methoxy-2-naphthyl) propionic acid having melting point below 50.degree. C. of formula: ##STR1## wherein R.sub.1 =a C.sub.2 -C.sub.10 alkyl, C.sub.4 -C.sub.6 cycloalkyl, phenyl, tetrahydropyranyl , tetrahydrofuranyl radicals and PA1 --(CH.sub.2 CH.sub.2 O).sub.n --R.sub.2 group, wherein PA1 n=2-15 and PA1 R.sub.2 =a C.sub.1 -C.sub.4 alkyl group, with the Lipase obtained from Candida Cylindracea, at temperatures ranging from 20.degree.-60.degree. C. and at a pH ranging from 5 to 8, by feeding said ester in a continuous way into a bioreactor containing said Lipase immobilized on a porous carrier selected from adsorbent resins of the polyacrylester type having a porosity ranging from 50 to 1000 .ANG. and a granulometry ranging from 1 to 0.01 mm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.