Antiinflammatory peptide derived from human lipocortin V
US5229367A · kind A · utility
7Cited by
2References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 1991 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Jan 18, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH (SEQ ID NO. 1) and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. The peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.