Method for relieving anxiety using 5-hydroxytryptamine-1A-receptor-binding compounds
US5229412A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1988 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Mar 25, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D237/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds that selectively bind 5-HT.sub.1A receptors in preference to other 5-HT receptors are provided along with methods for their use. Such compounds have the formula ##STR1## wherein A is an aromatic group selected to provide, with the glycidyl residue that forms the next portion of the molecule, a 5-HT-like portion of the molecule that represents the primary binding site of the molecule with a 5-HT receptor: X represents a quarternary carbon and its attached alkyl groups: Y represents a hydrocarbon linking group: Z represents hydrogen or an organic group containing up to 12 carbon and/or heteroatoms in its skeletal structure: and R.sup.1 and R.sup.2 independently represent hydrogen or an alkyl group. The aromatic group is most preferably indole or an indole derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.