Diamine compounds
US5229414A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 2, 1991 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | May 2, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/155
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the general formula I ##STR1## wherein R.sup.1 represents a halophenyl, dihalophenyl, nitrophenyl, cyanophenyl or trifluoromethylphenyl group; PA1 X represents a single bond, --CH.sub.2 --, --OCH.sub.2 --, SCH.sub.2, --S(O)--CH.sub.2 --, --S(O).sub.2 --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- PA1 R.sup.2 represents hydrogen or C.sub.1-3 alkyl; PA1 R.sup.3 represents a phenyl group substituted in the meta-position by a radical containing an organic base, an organic acid or a quaternary ammonium salt and optionally further substituted. PA1 R.sup.4 and R.sup.5 which may be the same or different each represents a C.sub.3-5 alkenyl, C.sub.3-5 alkynyl, C.sub.1-6 alkyl, or C.sub.4-7 cycloalkylalkyl group, or together with the intervening nitrogen atom represents a 4-7 membered heterocyclic ring, and the pharmaceutically acceptable salts thereof are useful for the treatment of hypertension and/or inflammation in the warm-blooded animals. Also disclosed are processes for their preparation and pharmaceutical compositions containing them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.