.beta.-lactams useful in determining the amount of elastase in a clinical sample
US5229510A · kind A · utility
24Cited by
11References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1992 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Jan 3, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are .beta.-lactams of formula I ##STR1## wherein X is a chromogenic or fluorogenic substituted aryl or heteroaryl, which are specific inhibitors of Human leukocyte elastase (HLE). Upon contact with HLE these compounds are cleaved to form a chromogenic or fluorogenic species which may be readily measured by the assay disclosed herein. The assay thus provides a means for direct measurement of the amount of active HLE in a body fluid or other sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.