Enzymatic process for separating the optical isomers of racemic 1,2-diols using lipase

US5231027A · kind A · utility

Assignee

• Ministero dell 'Universita'e della Ricerca Scientifica e Technologica · IT

Inventors

• Daniele Bianchi · Milano, IT
• Aldo Bosetti · Vercelli, IT
• Pietro Cesti · Trecate, IT
• Paolo Golini · Reggio nell'Emilia, IT
• Sandro Spezia · Piacenza, IT

Key dates

• Filing date: Sep 5, 1991
• Grant date: Jul 27, 1993
• Expiry date: Sep 5, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/004
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The optical isomers of racemic 1,2-diols are separated by enzymatic way, by eans of a process involving the following operations: PA0 reaction of the racemic mixture of the 1,2 diols with an organic anhydride in the presence of enzyme belonging to the class of lipases; PA0 separation of the enzyme; PA0 removal of the excess of anhydride; PA0 separation of the produced esters, in optically pure form by column chromatography; PA0 recovery of the 1,2 diols, as optically pure enantiomers.