Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia

US5231083A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Linz · Mainz, DE
• Bernward Scholkens · Kelkheim, DE
• Wolfgang Scholz · Beverly, US
• Gabriele Wiemer · Kronberg, DE
• Hansjorg Urbach · Kronberg, DE
• Rainer Henning · Tokyo, JP
• Volker Teetz · Hofheim, DE

Key dates

• Filing date: Aug 9, 1990
• Grant date: Jul 27, 1993
• Expiry date: Aug 9, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is hydrogen or an organic radical, and R.sup.4 and R.sup.5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.