2'isodideoxy-.beta.-D-nucleosides as stable antiviral agents
US5231174A · kind A · utility
0Cited by
13References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 27, 1992 |
| Grant date | Jul 27, 1993 |
| Priority date | — |
| Expiry date | Feb 27, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'.beta.-D-nucleosides and their derivatives where the base moiety has .beta.-stereochemistry but is transposed from the normal 1'-position to the 2'-position and the carbohydrate moiety has the D-configuration at the 4'-position. These compounds are resistant towards hydrolytic cleavage of the glycosidic bond and are resistant to enzymatic deamination. They have potential in the treatment or prophylaxis of viral infections, particularly retroviral infections and especially AIDS.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.