Imidazole compounds, processes for their preparation, pharmaceuticals based on these compounds and some intermediates

US5232922A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf Graeve · Taunusstein, DE
• Ismahan Okyayuz-Baklouti · Wiesbaden, DE
• Dirk Seiffge · Hochheim, DE

Key dates

• Filing date: Feb 8, 1991
• Grant date: Aug 3, 1993
• Expiry date: Feb 8, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazole compounds of the formula I ##STR1## in which R.sup.1 =alkyl, PA1 R.sup.2 and R.sup.3 =H, halogen or alkyl, PA1 X=OH or an amide radical having certain substituents, processes for their preparation and pharmaceuticals based on these compounds, in particular for the prophylaxis and treatment of circulatory disturbances, especially of disturbances of the microcirculation and of the disorders resulting therefrom, and some novel intermediates for the preparation of the compounds of the formula I, which are 1-methyl-, 1,2-dimethyl- and 1-ethyl-4-imidazolesulfonyl chloride.