2-heteroaryl-substituted benzodioxoic having 5-lipoxygenase inhibitory activity
US5232930A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jan 9, 1992 |
| Grant date | Aug 3, 1993 |
| Priority date | — |
| Expiry date | Jan 9, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a benzodioxole derivative of the formula I ##STR1## wherein Ar.sup.1 is an optionally substituted 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; PA1 R.sup.1 is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and PA1 R.sup.2 and R.sup.3 together form a group of the formula --A.sup.1 --X--A.sup.2 -- which, together with the carbon atom to which A.sup.1 and A.sup.2 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A.sup.1 and A.sup.2 is (1-3C)alkylene and X is oxy, thio, sulphinyl or sulphonyl, and which ring may bear one or two substituents; PA1 or a pharmaceutically-acceptable salt thereof; PA1 which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.