Chroman derivatives

US5232944A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Manfred Baumgarth
• Ingeborg Lues · Darmstadt, DE
• Jacques De Peyer · Darmstadt, DE
• Rolf Bergmann

Key dates

• Filing date: Apr 20, 1992
• Grant date: Aug 3, 1993
• Expiry date: Apr 20, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel chroman derivatives of the formula I ##STR1## in which X is O or NR.sup.11, PA1 Z is CH.sub.2, O, S or CHHal, PA1 R.sup.1 and R.sup.5 are each A, PA1 R.sup.2 is H or A, PA1 R.sup.1 and R.sup.2 together are also alkylene having 3-6 C atoms, PA1 R.sup.3 is OH or OAc, PA1 R.sup.4 is H, PA1 R.sup.3 and R.sup.4 together are also a bond, PA1 R.sup.6 and R.sup.7 are each H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO--CS, ACOO, A--CS--O, hydroxyalkyl, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, ASO, ASO.sub.2, AO--SO, AO--SO.sub.2, AcNH, AO--CO--NH, H.sub.2 NSO, HANSO, A.sub.2 NSO, H.sub.2 NSO.sub.2, HANSO.sub.2, A.sub.2 NSO.sub.2, H.sub.2 NCO, HANCO, A.sub.2 NCO, H.sub.2 NCS, HANCS, A.sub.2 NCS, ASONH, ASO.sub.2 NH, AOSONH, AOSO.sub.2 NH, ACO-alkyl, nitro-alkyl, cyanoalkyl, A--C(.dbd.NOH) or A--C(.dbd.NNH.sub.2), PA1 R.sup.8 and R.sup.9 are each H or A or together are .dbd.O or .dbd.S, PA1 R.sup.10 is H, Hal, CHO or CH.sub.2 OH, PA1 R.sup.11 is H, A, Ac or CH.sub.2 OH, PA1 m is 1, 2 or 3, PA1 Hal is F, Cl, Br or I, PA1 A is alkyl having 1-6 C atoms, PA1 -alkyl is alkylene having 1-6 C atoms and PA1 Ac is alkanoyl having 1-8 C atoms or aroyl having 7-11 C atoms, and …