Phenylethanolamines, their use as pharmaceuticals and as performance enhancers in animals

US5232946A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Rudolf Hurnaus · Großenhain, DE
• Manfred Reiffen · Biberach, DE
• Robert Sauter · Biberach, DE
• Wolfgang Grell · Biberach, DE
• Eckhard Rupprecht · Dinkelsbühl, DE

Key dates

• Filing date: Aug 20, 1990
• Grant date: Aug 3, 1993
• Expiry date: Aug 20, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new phenylethanolamines of general formula ##STR1## wherein A represents a straight-chained or branched alkylene group, PA0 B represents a bond, an alkylene group, a carbonyl or hydroxymethylene group, PA0 R.sub.1 represents a hydrogen atom, a halogen atom or a trifluoromethyl group, PA0 R.sub.2 represents a hydrogen atom or an amino group, PA0 R.sub.3 represents a cyano group, a hydrogen, chlorine or bromine atom and PA0 R.sub.4 represents a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl group or an alkoxy group substituted in the end position by a carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, pyrrolidino, piperidino or hexamethyleneimino group, PA0 the optical isomers and diastereoisomers and acid addition salts thereof. The new compounds of formula I, the optical isomers and diastereoisomers and acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof with inorganic or organic acids, have valuable pharmacological properties, namely an effe…