1-(2-arylethyl)-pyrrolidines

US5232978A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rudolf Gottschlich · Reinheim, DE
• Karl-August Ackermann · Ober-Ramstadt, DE
• Helmut Prucher · Heppenheim, DE
• Andrew Barbar · Weiterstadt, DE
• Anton Haase · Bogen, DE
• Hartmut Greiner · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE

Key dates

• Filing date: Nov 1, 1991
• Grant date: Aug 3, 1993
• Expiry date: Nov 1, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 1-(2-arylethyl)-pyrrolidines of the formula ##STR1## in which, Ar is a phenyl group which is unsubstituted or monosubstituted by OH, --O--CO--NH.sub.2, --O--CO--NHA, --O--CO--NA.sub.2, NH.sub.2, --NH--CHO, --NH--CO--A, --NH--CO--NH.sub.2, --NH--CO--NHA or NH--SO.sub.2 --A, PA1 R.sup.1 is A, PA1 R.sup.2 is a phenyl, naphthyl, thienyl, benzothienyl or pyridyl group which is unsubstituted or mono- or disubstituted by A, Hal, CF.sub.3, OH, OA, --O--CO--NH.sub.2, --O--CO--NHA, --O--CO--NA.sub.2, NO.sub.2, NH.sub.2, --NH--CHO, --NH--CO--A, --NH--CO--NH.sub.2, --NH--CO--NHA, --NH--SO.sub.2 A, --CO--A, --CONH.sub.2, --CONHA, --CONA.sub.2, --CH.sub.2 --CONH.sub.2 and/or --O--CH.sub.2 --CONH.sub.2, PA1 R.sup.3 is OH or CH.sub.2 OH, PA1 A is alkyl with 1-4 C atoms and PA1 Hal is F, Cl, Br or I, or a pharmaceutically acceptable salt thereof for use as an analgesic in humans and veterinary medicine.