Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5234690A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 23, 1991 |
| Grant date | Aug 10, 1993 |
| Priority date | — |
| Expiry date | Aug 23, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A delayed onset transdermal drug delivery device exhibiting a delay period of at least six hours comprising a laminated composite of (1) a top backing layer; (2) a pressure rupturable layer underlying (1); (3) a reservoir of a solution of drug in a liquid vehicle between (1) and (2); (4) a wick layer underlying (2) for dispersing the drug once (2) is ruptured; (5) a first adhesive layer underlying (4) that is permeable to the drug; (6) a microporous membrane underlying (5) which is itself impermeable to the drug and whose pores are substantially unfilled prior to application of the device to the skin; and (7) a second adhesive layer underlying (6) that is permeable to the drug but is immiscible in the polymer filling the pores of (6).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.