Patent · US Expired

N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters

US5234935A · kind A · utility

10Cited by

7References

9Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Otto Behner · Wuppertal, DE
Hartmut Wollweber · Wuppertal, DE
Bruno Rosen · Wülfrath, DE
Siegfried Zaiss · Wuppertal, DE
Siegfried Goldmann · Wuppertal, DE

Key dates

Filing date	Apr 4, 1991
Grant date	Aug 10, 1993
Priority date	—
Expiry date	Apr 4, 2011

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl, PA0 R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl, PA0 R.sup.3 represents hydrogen or cyano, or PA0 R.sup.2 and R.sup.3 together form a fused benzo ring, PA0 R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, and PA0 R.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms. Many of the compounds are new.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.