Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
US5235049A · kind A · utility
37Cited by
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Key dates
| Filing date | Jan 24, 1989 |
| Grant date | Aug 10, 1993 |
| Priority date | — |
| Expiry date | Jan 24, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/827
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1 are substantially the same. ICAM-1 is involved in the process through which lymphocytes attach to cellular substrates during inflammation and serves as the major human rhinovirus receptor (HRR). sICAM-1 therefore has both the property of reducing immune inflammation and inhibiting infection of rhinovirus and Coxsackie A virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.