Heparin-selective polymeric membrane electrode

US5236570A · kind A · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shu-Ching Ma · Ann Arbor, US
• Mark E. Meyerhoff · Ann Arbor, US
• Victor C. Yang · Ann Arbor, US

Key dates

• Filing date: Mar 10, 1992
• Grant date: Aug 17, 1993
• Expiry date: Mar 10, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/817
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An anion exchange membrane for ionic macromolecules, specifically heparin, which is formed of a polymeric matrix material, an anion exchange material suitable for heparin detection, and a plasticizer can be employed in an electrochemical sensor arrangement to directly measure the concentration of heparin ions in blood or blood fluid. Potentiometric response to heparin has been observed with membranes comprising 30-70 wt. % polymeric matrix material, such as polyvinyl chloride, 0.1-12 wt. % quaternary ammonium salt, such as tridodecyl methyl ammonium chloride, and 30-70 wt. % of a plasticizer, such as dioctyl sebacate.