Sulphonamide derivatives
US5236948A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Jan 10, 1992 |
| Grant date | Aug 17, 1993 |
| Priority date | — |
| Expiry date | Jan 10, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns sulphonamide derivatives of the formula I ##STR1## wherein R.sup.1 includes (1-4C)alkyl; PA0 R.sup.2 and R.sup.3 together form --A.sup.2 --X.sup.2 --A.sup.3 -- which defines a ring having 5 to 7 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3 C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl; PA0 A.sup.1 is a direct link to X.sup.1 or is (1-3 C)alkylene; PA0 X.sup.1 is oxy, thio, sulphinyl, sulphonyl or imino; PA0 Ar is optionally substituted phenylene or Ar is pyridylene; PA0 Q is nitrogen or of the formula CR.sup.7, wherein R.sup.7 includes hydrogen, halogeno, (1-4 C)alkyl and (1-4 C)alkoxy; PA0 each of R.sup.4 and R.sup.5 is (1-4 C)alkyl, (3-4 C)alkenyl, (3-4 C)alkynyl or optionally substituted phenyl, benzyl or pyridyl, or R.sup.5 may be hydrogen; and PA0 R.sup.6 has any of the meanings defined for R.sup.7 ; or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.