Patent · US Expired

Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids

US5237060A · kind A · utility

5Cited by

3References

3Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Michael Schriewer · Odenthal, DE
Klaus Grohe · Odenthal, DE
Hans-Joachim Zeiler · Velbert, DE
Karl G. Metzger · Wuppertal, DE

Key dates

Filing date	Feb 23, 1989
Grant date	Aug 17, 1993
Priority date	—
Expiry date	Feb 23, 2009

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of highly antibacterially active enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives of the formula (I) ##STR1## in which 1) a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## to form a compound of the formula ##STR4## followed by cyclization to form a compound of the formula ##STR5## and further cyclization to form a compound of the formula ##STR6## an finally reaction of the cyclized product with amines of the formula ##STR7##

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.