Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy
US5237066A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1991 |
| Grant date | Aug 17, 1993 |
| Priority date | — |
| Expiry date | Sep 17, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Enantiomer of absolute configuration S of formula: ##STR1## where: X=O or S; and PA0 Ar denotes a: PA1 * phenyl ring substituted with one, two or three C.sub.1 -C.sub.4 alkoxy groups; PA1 * phenyl ring substituted at the 2-position with a OCH.sub.3 group and at the 5-position with a halogen atom or a lower alkylcarbonyl group; PA1 * phenyl ring substituted at the 2-position with OCH.sub.3, at the 4-position with NH.sub.2 or alkylcarbonyl-NH and at the 5-position with a halogen; PA1 * 3-fluoro-2-methoxyphenyl group; PA1 * 5-pyrimidinyl group substituted at the 2-position with NH.sub.2 and in the 4-position with alkoxy or phenyloxy. These compounds are useful as medicinal products having activity in respect of gastric movements and antiemetic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.