Efficient microcapsule preparation and method of use
US5238714A · kind A · utility
81Cited by
8References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 2, 1990 |
| Grant date | Aug 24, 1993 |
| Priority date | — |
| Expiry date | Oct 2, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers. In a particular aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing targeting to specific tissue cells. Encapsulation of hydrophilic radiodiagnostic agents in 1 .mu.m capsules provides improved opacification. Encapsulation of cytotoxic agents in 100 .mu.m capsules is useful in chemoembolization procedures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.