Method for the preparation of an optically active 2-substituted carboxylic acid
US5238828A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 17, 1991 |
| Grant date | Aug 24, 1993 |
| Priority date | — |
| Expiry date | Sep 17, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An efficient microbiological or biochemical method is proposed for the preparation of an optically active 2-substituted carboxylic acid, e.g., 2-chloropropionic acid, 2-methyl butyric acid and the like, from the corresponding 2-substituted nitrile compound, e.g., 2-chloropropionitrile, 2-methyl butyronitrile and the like, in the form of a racemic body as the starting material The method comprises bringing the starting nitrile compound into contact with a microorganism, such as Pseudomonas sp. MY-1 (FERM BP-2541), Fusarium sp. MY-2 (FERM BP-2542) and the like, capable of converting the nitrile compound into the carboxylic acid in a buffered aqueous medium in which the microbial cells of the microorganism are suspended.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.